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Validization of diagnostic methods in PTSD
Vágnerová, Anna ; Preiss, Marek (advisor) ; Heider, David (referee)
With this work, I became involved in an ongoing project of tool validation for measuring psychological trauma within the activities of the National Institute of Mental Health - Validation of tools for measuring psychological trauma. The aim of this thesis was to collect data from a clinical population with posttraumatic stress disorder (PTSD) and compare it with the results of diagnostic methods in the general population (N=303). The research clinical sample consisted of 31 respondents who, based on diagnostic criteria for PTSD diagnosis according to DSM-5, were divided into two research groups - with a probable PTSD diagnosis (N=17) and without a probable PTSD diagnosis (N=14). In this work, the results of three research groups were compared using the PTSD Checklist 5 method, which assesses the level of traumatization, and the Life Events Checklist-5 method, which examines the frequency of experienced traumatic events. At the same time, measurement of depressive and anxious symptoms of all participants was conducted to assess convergent validity. The results of statistical analysis showed that the PCL-5 method proved to be valid. The group with a probable PTSD diagnosis achieved statistically significantly higher values than the general population group, even in the results of methods measuring...
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Assessment of Parkinson’s Disease Based on Acoustic Analysis of Hypokinetic Dysarthria
Galáž, Zoltán ; Brezany, Peter (referee) ; Sklenář, Jaroslav (referee) ; Mekyska, Jiří (advisor)
Hypokinetická dysartrie (HD) je častým symptomem vyskytujícím se až u 90% pacientů trpících idiopatickou Parkinsonovou nemocí (PN), která výrazně přispívá k nepřirozenosti a nesrozumitelnosti řeči těchto pacientů. Hlavním cílem této disertační práce je prozkoumat možnosti použití kvantitativní paraklinické analýzy HD, s použitím parametrizace řeči, statistického zpracování a strojového učení, za účelem diagnózy a objektivního hodnocení PN. Tato práce dokazuje, že počítačová akustická analýza je schopná dostatečně popsat HD, speciálně tzv. dysprozodii, která se projevuje nedokonalou intonací a nepřirozeným tempem řeči. Navíc také dokazuje, že použití klinicky interpretovatelných akustických parametrů kvantifikujících různé aspekty HD, jako jsou fonace, artikulace a prozodie, může být použito k objektivnímu posouzení závažnosti motorických a nemotorických symptomů vyskytujících se u pacientů s PN. Dále tato práce prezentuje výzkum společných patofyziologických mechanizmů stojících za HD a zárazy v chůzi při PN. Nakonec tato práce dokazuje, že akustická analýza HD může být použita pro odhad progrese zárazů v chůzi v horizontu dvou let.
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Infection of salmonelosis, their source and diagnosis.
Valkus, Martin ; Veselá, Mária (referee) ; Vránová, Dana (advisor)
This bachelor‘s thesis deals with infection of salmonelosis, it’s source, prevention and diagnosis. Theoretical part includes general information about Salmonella species and its morphology. It describes pathogenesis, source of infection, clinical symptoms, treatment and diet recommendations. It analyzes statistics of number of infection occurrences in Czech Republic. It also deals with prevention of infection origin on schools, population foreknowledge and climatic effects. Experimental part of this thesis contains description of optimization procedure of identification Enterobacteriaceae by adjusting of pH of prepared medium MIU.
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Computer analysis of medical image data
Krajčír, Róbert ; Šmirg, Ondřej (referee) ; Uher, Václav (advisor)
This work deals with medical image analysis, using variety of statisic and numeric methods implemented in Eclipse and Rapidminer environments in Java programming language. Sets of images (slices), which are used here, are the results of magnetic resonance brain examination of several subejcts. Segments in this 3D image are analyzed and some local features are computed, based on which data sets for use in training algorythms are generated. The ability of successful identification of healthy or unhealthy tissues is then practically tested using available data.
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Technical survey of the family house
Odstrčil, Štěpán ; Láník, Jaromír (referee) ; Schmid, Pavel (advisor)
This bachelor’s thesis deals with diagnostics of one object divided to 4 residence units. Technical construction resarch had to be made due to owned wants knock down his residence unit and build a new family house instead o fit. Object is located on the street Žebětínek 17 in Brno-Medlánky. Resarch includes enumeration of all damages before demoliton o rafter that, diagnostics of object wich is being demolished and consequences of demolition to buildings nearby.
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Sestem for removal of children speech defects
Pokorný, Vojtěch ; Sekora, Jiří (referee) ; Harabiš, Vratislav (advisor)
Speech is one of the basic forms of human communication and disruption of communication ability can negatively affect the life of man. deals with the elaboration of logopedic theory, which serves as a basis for the follow-up design and application creation in the field of speech therapy. The thesis is divided into five chapters. The first chapter deals with the history of speech therapy with an emphasis on domestic logopaedia, the logopedic intervention process in its entirety, and the differentiation of individual types of impaired communication skills. The second chapter focuses on a specific disruption of communication skills - dyslalia.The application for the treatment of dyslalia is determined by the application, which is elaborated in the third chapter. The fourth chapter contains a detailed description of the designed and created application, including an explanation of the processes running in the application when the application is being used. The last chapter of this diploma thesis contains a summary of the results of the practical testing of the application together with suggestions for improvement of the application.
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Analysis of Speech Signals for the Purpose of Neurological Disorders IT Diagnosis
Mekyska, Jiří ; Dostál, Otto (referee) ; Přibilová, Anna (referee) ; Smékal, Zdeněk (advisor)
This work deals with a design of hypokinetic dysarthria analysis system. Hypokinetic dysarthria is a speech motor dysfunction that is present in approx. 90 % of patients with Parkinson’s disease. The work is mainly focused on parameterization techniques that can be used to diagnose or monitor this disease as well as estimate its progress. Next, features that significantly correlate with subjective tests are found. These features can be used to estimate scores of different scales like Unified Parkinson’s Disease Rating Scale (UPDRS) or Mini–Mental State Examination (MMSE). A protocol of dysarthric speech acquisition is introduced in this work too. In combination with acoustic analysis it can be used to estimate a grade of hypokinetic dysarthria in fields of faciokinesis, phonorespiration and phonetics (correlation with 3F test). Regarding the parameterization, features based on modulation spectrum, inferior colliculus coefficients, bicepstrum, approximate and sample entropy, empirical mode decomposition and singular points are originally introduced in this work. All the designed techniques are integrated into the system concept in way that it can be implemented in a hospital and used for a research on Parkinson’s disease or its evaluation.
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Preparation and Realization of Technical Survey of the Building
Brothánek, Jan ; Heřmánková, Věra (referee) ; Anton, Ondřej (advisor)
This thesis covers structural-technic research of family house situated in Brno. In the first part of thesis I discuss theoretical explanation of structures situated in the object and its assessment in vterms of structural engineering research. Goal of this research is to estimate strength of masonry. These properties are calculated in practical part of this thesis. Last part of thesis summarizes previous calculations of strength of masonry.
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Acoustic analysis of sentences complicated for articulation in patients with Parkinson's disease
Kiska, Tomáš ; Smékal, Zdeněk (referee) ; Mekyska, Jiří (advisor)
This work deals with a design of hypokinetic dysarthria analysis system. Hypokinetic dysarthria is a speech motor dysfunction that is present in approx. 90 % of patients with Parkinson’s disease. Next there is described Parkinson's disease and change of the speech signal by this disability. The following describes the symptoms, which are used for the diagnosis of Parkinson's disease (FCR, VSA, VAI, etc.). The work is mainly focused on parameterization techniques that can be used to diagnose or monitor this disease as well as estimate its progress. A protocol of dysarthric speech acquisition is described in this work too. In combination with acoustic analysis it can be used to estimate a grade of hypokinetic dysarthria in fields of faciokinesis, phonorespiration and phonetics (correlation with 3F test). Regarding the parameterization, new features based on method RASTA. The analysis is based on parametrization sentences complicated for articulation. Experimental dataset consists of 101 PD patients with different disease progress and 53 healthy controls. For classification with feature selection have selected method mRMR.
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